Our objectives are:
To determine the MRSA disease burden and prevalence in humans and in animals in three countries/ areas (Bangladesh, Sri Lanka, China and Hong Kong SAR) through systematic reviews of the literature available;
Presented by Bella YANG
To identify the research gaps in the One Health context of human-animal environment interactions on MRSA in these countries;
To conduct specific studies to isolate MRSA from human, animal and environmental sources and to characterize the strains through phenotypic and molecular typing.
Table 1 Investigation settings for MRSA prevalence, carriage and contamination studies.
To understand the interrelationship between MRSA clones, their antimicrobial and biocide resistance determinants, virulence associations from a human-animal-environmental context.
A total of 564 single patient MRSA isolates from the period 2009-2016 underwent molecular characterization via whole genome sequencing (WGS). The prevalence of sequence types was as follow: ST22 (33%), followed by ST45 (32%) and ST1774 (17%) (Figure 1). Analysis is still ongoing, and another 728 strains from the period 2017-2024 are queued for WGS.
Pie chart of prevalent sequence types (ST) in 564 Hong Kong MRSA isolates, 2009-2016.
