Adrian Jun CHU

Adrian Jun CHU

BSc (Hons), PhD
Research Assistant Professor,
Department of Microbiology,
Faculty of Medicine, The Chinese University of Hong Kong

Professor Adrian Jun CHU

adrianjunchu@cuhk.edu.hk

Research

ORCID: orcid.org/0000-0001-9206-9395

Google Scholar

https://scholar.google.com.hk/citations?user=IuGdOqYAAAAJ&hl

Research interest
Antimicrobial drug discovery
Pathogenicity and virulence of drug-resistant bacteria
Development of novel anti-tuberculous agents
Awards
YearAwards
Bronze Medal48th International Exhibition of Inventions Geneva, 2023
Postdoctoral Fellowship Scheme
(2021 – 2022)
Research Committee, The Chinese University of Hong Kong
Research Fellowship Scheme
(2020 – 2021)		Research Committee, The Chinese University of Hong Kong
Faculty Postdoctoral Fellowship Scheme
(2019 – 2021)		Faculty of Medicine, The Chinese University of Hong Kong
Publications (Representative)
Note: *Equal contribution

  1. Lam NM, Tsang TF, Qu J, Tsang MW, Tao Y, Kan CH, Zou Q, Chan KH, Chu AJ, Ma C, Yang X. (2024) Development of a luciferase-based Gram-positive bacterial reporter system for the characterization of antimicrobial agents. Appl. Environ. Microbiol. 90(8), e00717-24.
  2. Ye J, Kan CH, Zheng Y, Tsang TF, Chu AJ, Chan KH, Yang X, Ma Cong. (2024) Sufonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria. Bioorg. Chem. 143, 106983.
  3. Qiu Y*, Chu AJ*, Tsang TF, Zheng Y, Lam NM, Li KSL, Ip M, Yang X, Ma C. (2022) Synthesis and biological evaluation of nusbiarylin derivatives as bacterial rRNA synthesis inhibitor with potent antimicrobial activity against MRSA and VRSA. Bioorg. Chem. 124, 105863.
  4. Black CM*, Chu AJ*, Thomas GH, Routledge A, Duhme-Klair AK. (2022) Synthesis and antimicrobial activity of an SO2-releasing siderophore conjugate. J. Inorg. Biochem. 234, 111875.
  5. Ngai HL, Yang X, Chu AJ, Harper R, Jacobsen ABJE, Lau DTW, Yu HY, Lee HK, Shaw PC. (2022) Multi-methodological approach for the Quality assessment of Senecionis scandentis Herba (Qianliguang) in the herbal market. PLOS ONE 17(4), e0267143.
  6. Ye J*, Chu AJ*, Lin L, Chan ST, Harper R, Xiao M, Artsimovitch I, Zuo Z, Ma C, Yang X. (2020) Benzyl and benzoyl benzoic acid inhibitors of bacterial RNA polymerase-sigma factor interaction. Eur. J. Med. Chem. 208, 112671.
  7. Chu AJ, Qiu Y, Harper R, Lin L, Ma C, Yang X. (2020) Nusbiarylins inhibit transcription and target virulence factors in bacterial pathogen Staphylococcus aureus. Int. J. Mol. Sci. 21(16), 5772.
  8. Ye J, Chu AJ, Harper R, Chan ST, Shek TL, Zhang Y, Ip M, Sambir M, Artsimovitch I, Zuo Z, Yang X, Ma C. (2020) Discovery of Antibacterials That Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors. J. Med. Chem. 63(14), 7695-7720. Supplementary Cover Article.
  9. Ye J*, Chu AJ*, Lin L, Yang X, Ma C. (2019) First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae. Molecules. 24(16), 2902.

Start-up Company
Ynno Med Limited
Team Member
(Ynno Med Limited)		Technology Start-up Support Scheme for Universities
(TSSSU-O)		2024 – 2025
Team Member
(Ynno Med Limited)
Technology Start-up Support Scheme for Universities
(TSSSU-O)		2023 – 2024
Team Member
(Ynno Med Limited)		Technology Start-up Support Scheme for Universities
(TSSSU-O)		2022 – 2023
Team Member
(Ynno Med Limited)		CUHK Pi Centre2020 – 2021

www.ynnomed.com

Back