BOON Siaw Shi

Professor BOON Siaw Shi

Ph.D (Life and Biomolecular Science); MSc (Cancer Molecular Biology);
BSc (Biomedical Sciences)
Research Assistant Professor,
Department of Microbiology,
Faculty of Medicine, The Chinese University of Hong Kong

Professor BOON Siaw Shi

boonss@cuhk.edu.hk

Research

ORCID: orcid.org/0000-0001-9772-2971

Research interest
Viral pathogenesis
Cancer biology
Cell signalling pathways
Anti-viral compounds
Postgraduate students
Information for Postgraduate Study in Department of Microbiology
Our Team
Staff
Student
Awards
YearAwards
2019Travel Grant for Arturo Falaschi Conference Series – DNA Tumour Virus Meeting
2015Travel Grant for ICGEB DNA Tumour Virus Meeting
2010 – 2014ICGEB Fellowship
2006 – 2009UNIMAS Postgraduate Scholarship (Full Scholarship)
2002 – 2005Full Scholarship from Ministry of Public Service (JPA), Malaysia
Research Grants
Exploring the association between Aurora kinases and E6-encoded by human papillomaviruses (HPV) as a potential curative measure. CUHK Direct Grant 2023/24.
Exploring the potential and efficacy of deubiquitinases inhibitors as therapeutics for HPV-associated cancers. CUHK Direct Grant 2022/23.
Investigate the synergism of Aurora kinase A and HPV-encoded E6 in inducing carcinogenesis. CUHK Direct Grant 2020/21.
Characterization of genomic and functional features of human microbiome associated with oral cavity squamous cell carcinoma using multi-omics approaches. HMRF Ref: 19202041.
Delineate the Prevalence, Risk Factors, Temporal Distribution and Epidemiological Characteristics of Hidden Novel Coronavirus (SARS-CoV-2) Infection in the Community.
Anti-coronavirus drug discovery. PIEF-COVID. (PIEF/Ph2/COVID/19).
Association between oral microbiome, HPV and human epigenetic events in head and neck squamous cell carcinoma (RGC Ref. 14161017). 2018 – 2020.
The association between human papillomavirus (HPV) E6 oncoprotein and Aurora B in carcinogenesis – a potential horizon for therapeutic intervention. RGC Ref. 14162117. 2018 – 2022.
Publications (Representable publications; Number of publications: 43; h index: 16, Citation: 1308)
Note: *Corresponding author

  1. Ho WCS, Boon SS, Chong KC, Lai CKC, Sze RKH, Khan ATK, Xing RL, Sukarom I, Wu YH, Chau RWY, Chan PKS. Prevalence of oral human papillomavirus infection among general adult population in Hong Kong. JMV. 2024, 93(2):e29460.
  2. Chen Z, Chan ABW, Kam LS, Chan MH, Chan JYK, Lee WT, Chow C, Boon SS, Xia C, Lam B, Lam S, Ng R, Ho WCS, Lam EWH, Lai CKC, Chan PKS. Changes in the incidence and human papillomavirus-positive portion of oropharyngeal squamous cell carcinoma in Hong Kong. 2024, 16(1), 226.
  3. Skelin J, Luk HY, Butorac D, Boon SS*, Tomaic V*. The effects of HPV oncoproteins on host communication networks: Therapeutic connotations. Journal fo Medical Virology. 2023; 95:e29315.
  4. Xia C, Xiao C, Luk HY, Chan PKS, Boon SS*. The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis. Cellular and Molecular Life Sciences. 2023. 80:278.
  5. Ng RWY, Sze RKH, Chong KC, Zhao S, Ling L, Lui G, Leung ASY, Yeung ACM, Ho WCS, Wong MCS, Chen Z, Boon SS, Hui DSC, Chan PKS. Effectiveness of mRNA and inactivated COVID-19 vaccines: A test-negative study in an infection naïve Hong Kong population. Journal of Infection. S0163-4453(23)00298-0.
  6. Boon SS, Lee YCL, Yip KL, Luk HY, Xiao C, Yim MK, Chen Z, Chan PKS. Interaction between human papillomavirus-encoded E6 protein and AurB – a potential target of intervention. Cancers 2023, 15:2456.
  7. Skelin J, Luk HY, Butorac D, Boon SS*, Tomaic V*. The effects of HPV oncoproteins on host communication networks: Therapeutic connotations. Journal fo Medical Virology. 2023; 95:e29315.
  8. Xia C, Xiao C, Luk HY, Chan PKS, Boon SS*. The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis. Cellular and Molecular Life Sciences. 2023. 80:278.
  9. Boon SS, Lee YCL, Yip KL, Luk HY, Xiao C, Yim MK, Chen Z, Chan PKS. Interaction between human papillomavirus-encoded E6 protein and AurB – a potential target of intervention. Cancers 2023, 15:2456.
  10. Li S, Yim MK, Yip KL, Xiao C, Luk HY, Xiao S, Chen Z, Chan PKS, Boon SS*. E6-encoded by cancer-causing human papillomavirus interacts with Aurora kinase A to promote HPV-mediated carcinogenesis. Journal of Virology. 2023. 97(2):e01872-22.
  11. Boon SS (1/5), Luk HY, Xiao C, Chen Z, Chan PKS. Review of the standard and advanced screening, staging systems and treatment modalities for cervical cancer. Cancers 2022; 14(12):2913.
  12. Li S, Luk HY, Xia C, Chen Z, Chan PKS, Boon SS*. Oesophageal carcinoma: the prevalence of DNA tumour viruses and therapy. Tumour Virus Research 2022;13:200231.
  13. Boon SS, Xia C, Wang MH, Yip KL, Luk HY, Li S, Ng RWY, Lai CKC, Chan PKS, Chen Z. 2021. Temporal-geographical dispersion of SARS-CoV-2 spike glycoprotein variant lineages and their functional prediction using in silico approach. mBio 2021;12:e02687-21.
  14. Boon SS, Wong MCS, Ng RWY, Leung D, Chen Z, Lai CKC, Ho WCS, Hung J, Wong B, Fung K, Chan PKS. Seroprevalence studies of unidentified SARS-CoV-2 infection in Hong Kong during three pandemic waves. JAMA Netw Open. 2021; 4(11):e2132923.
  15. Xia C, Li S, Long T, Chen Z, Chan PKS, Boon SS*. Current updates on cancer-causing types of human papillomaviruses (HPVs) in East, Southeast and South Asia. Cancer 2021; 13(11):2691: doi:10.3390/cancers13112691.
  16. Chen Z, Wong PY, Ng CWK, Lan L, Fung S, Li JW, Cai L, Lei P, Mou Q, Wong SH, Wu WKK, Li RJ, Meehan K, Lui VWY, Chow C, Lo KW, Chan ABW, Boon SS, Lau EHL, Yeung Z, Chan KCA, Wong EWY, Cheng ASL, Yu J, Chan PKS, Chan JYK. The intersection between oral microbiota, host gene methylation and patient outcomes in head and neck squamous cell carcinoma. Cancer 2020; 12(11), 3425.
  17. Chan PKS, Lui G, Hachim A, Ko RLW, Boon SS, Li T, Kavian N, Luk F, Chen Z, Yau EM, Chan KH, Tsang CH, Cheng SMS, Chu DKW, Perera RAPM, Ho WCS, Yeung ACM, Chow C, Poon LLM, Valkenburg SA, Hui DSC, Peiris M. Serological responses in healthy adult with SARS-CoV-2 reinfection, Hong Kong 2020. Emerging Infectious Diseases 2020; 25(12). https://wwwnc.cdc.gov/eid/article/26/12/20-3833_article.
  18. Zuo T, Liu Q, Zhang F, Lui GC, Tso EY, Yeoh YK, Chen Z, Boon SS, Chan FK, Chan PK, Ng SC. Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19. Gut 2020:gutjnl-2020-322294.
  19. Boon SS, Xia C, Lim JY, Chen Z, Law PTY, Yeung CMA, Thomas M, Banks L, Chan PKS. Human papillomavirus 58 E7 T20I/G63S variant isolated from East Asian population possesses high oncogenicity. Journal of Virology 2020. doi: 10.1128/JVI.00090-20
  20. Boon SS, Chen Z, Li JT, Ho WCS, Lee YC, Chan PKS. Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly. BMC Cancer 2019. 1211. doi:10.1186/s12885-019-6413-7.
  21. Law PTY, Boon SS, Hu C, Lung RWM, Cheung GPY, Ho WCS, Chen Z, Massimi P, Thomas M, Pim D, Banks L, Chan PKS.  Oncogenicity Comparison of Human Papillomavirus Type 58 E7 Variants. Journal of Cellular and Molecular Medicine 2018;Doi:10.1111/jcmm.14059.
  22. Thatte J, Massimi P, Thomas M, Boon SS, Banks L. The Human Papillomavirus E6 PDZ Binding Motif Links DNA Damage Response Signaling to E6 Inhibition of p53 Transcriptional Activity. Journal of Virology 2018;92 (16): e00465-18.
  23. Boon SS, Tomaić, V., Roberts, S., Banks, L. Cancer-causing Human Papillomavirus E6 proteins displays major differences in the phospho-regulation of their PDZ interactions. Journal of Virology 2015, 89(3):1579-86.
  24. Boon SS and Banks L. High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner. Journal of Virology 2013, 87(3):1586-95.
  25. Pim D, Bergant M, Boon SS, Ganti K, Kranjec C, Massimi P, Subbaiah VK,Thomas M, Tomaic V, Banks L. Human papillomaviruses and the specificity of PDZ domain targeting. FEBS Journal 2012, 279(19):3530-7.
  26. Subbaiah VK, Massimi P, Boon SS, Myers MP, Sharek L, Garcia-Mata, R, Banks L. The Invasive Capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PLoS Pathogens 2012, 8(2): e1002543.

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