Rita WY NG

Professor Rita WY NG

MBChB (CUHK), MRCP (UK), FRCPath (UK), FHKCPath, FHKAM (Pathology)
Assistant Professor (Clinical),
Department of Microbiology,
Faculty of Medicine, Chinese University of Hong Kong
Honorary Associate Consultant in Microbiology,
New Territories East Cluster, Hong Kong Hospital Authority

Elite Alumni Microbiologist,
Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong

Assessor of Hong Kong Accreditation Service (HKAS)

Professor Rita WY NG

ritang@cuhk.edu.hk

Research

ORCID: orcid.org/ 0000-0003-4966-3350

Research interest
Microbiome
Clinical microbiology & infectious diseases
Infection control
Awards
Faculty Postdocoral Fellowship Scheme 2021-2022
Postgraduate students
Information for Postgraduate Study in Department of Microbiology
Our Team
Staff
Research Grants
Single cell DNA sequencing for profiling gut microbiome in healthy Faecal Microbiota Transplantation donors and patients with Clostridiodes difficile
General Research Fund (GRF) / University Grants Committee (Hong Kong)
Principle Investigator
The role of gut microbiome in attention deficit hyperactivity disorder (ADHD) and its response to methylphenidate: A Southern Chinese study
Early Career Scheme (ECS) / University Grants Committee (Hong Kong)
Principle Investigator
Effect of Gut microbiota from ADHD on brain structure, behavioural characteristics and gut microbiota profile in a Human Microbiota-Associated mouse model
Direct Grant for Research
Principle Investigator
Optimisation of clinical treatment of severe influenza to reduce morbidity and mortality
Health and Medical Research Fund
Co-Investigator
Delineate the prevalence, risk factors, temporal distribution and epidemiological characteristics of hidden novel coronavirus (SARS-CoV-2) infection in the community
Health and Medical Research Fund
Co-Investigator
Comprehensive clinical, virological, microbiological, immunological and laboratory monitoring of patients hospitalized with Coronavirus Diseases (COVID-19)
Health and Medical Research Fund
Co-Investigator
Early biomarkers in SARS-CoV-2 infection: correlation with short/medium/long-term clinical outcomes, and implications on acute patient management and long-term medical and health care
Food and Health Bureau (Hong Kong)
Co-Investigator
Publications (All)

  1. 1. Chen Z, Fung E, Wong CK, Ling L, Lui G, Lai CKC, Ng RWY, Sze RKH, Ho WCS. Hui DSC, Chan PKS. Early Metabolomic and Immunologic Biomarkers as Prognostic Indicators for COVID-19. Metabolites. 2024 Jul 9;14(7):380. doi: 10.3390/metabo14070380.
  2.  Chen Z, Ng RWY, Lui G, Ling L, Leung ASY, Chow C, Boon SS, Ho WCS, Wang MH, Chan RWY, Li AM, Hui DSC, Chan PKS. Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G. Virol Sin. 2024 Feb 3:S1995-820X(24)00010-5. doi: 10.1016/j.virs.2024.01.010
  3. Huang B, Huang J, Chiang NH, Chen Z, Lui G, Ling L, Kwan MYW, Wong JSC, Mak PQ, Ling JWH, Lam ICS, Ng RWY, Wang X, Gao R, Hui DSC, Ma SL, Chan PKS, Tang NLS. Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients. Front Immunol. 2024 Jan 10:14:1315602. doi: 10.3389/fimmu.2023.1315602.
  4. Chen Z, Chan ABW, Kam LS, Chan MH, Chan JYK, Lee WT, Chow C, Boon SS, Xia C, Lam B, Lam S, Ng RWY, Ho WCS, Lam EWH, Lai CKC, Chan PKS. Changes in the Incidence and Human Papillomavirus-Positive Portion of Oropharyngeal Squamous Cell Carcinoma in Hong Kong. Cancers (Basel). 2024 Jan 3;16(1):226. doi: 10.3390/cancers16010226.
  5. Cheung MK, Leung TF, Tam WH, Leung ASY, Chan OM, Ng RWY, Yau JWK, Yuen LY, Tong SLY, Ho WCS, Yeung ACM, Chen Z, Chan PKS. Development of the early-life gut microbiome and associations with eczema in a prospective Chinese cohort. mSystems. 2023 Oct 26;8(5):e0052123. doi: 10.1128/msystems.00521-23
  6. Cheung MK, Ng RWY, Lai CKC, Zhu C, Au ETK, Yau JWK, Li C, Wong HC, Wong BCK, Kwok KO, Chen Z, Chan PKS. Lui GCY, Ip Margaret. Alterations in faecal microbiome and resistome in Chinese international travellers: a metagenomics analysis. J Travel Med. 2023 Mar 2;taad027. DOI: 10.1093/jtm/taad027.
  7. Ng RWY, Sze RKH, Chong KC, Zhao S, Ling L, Lui G, Leung ASY, Yeung ACM, Ho WCS, Wong MCS, Chen Z, Boon SS, Hui DSC, Chan PKS. Effectiveness of mRNA and inactivated COVID-19 vaccines: a test-negative study in an infection-naïve Hong Kong population. J Infect. 2023 May 26;S0163-4453(23)00298-0. DOI: 10.1016/j.jinf.2023.05.020
  8. Ng RWY, Dharmaratne P, Wong S, Hawkey P, Chan PKS, Ip Margaret. Revisiting the donor screening protocol of faecal microbiota transplantation (FMT): a systematic review. Gut. 2023 May 4;gutjnl-2023-329515. DOI: 10.1136/gutjnl-2023-329515
  9. Gao X, Chan PKS, Wong KCY, Ng RWY, Yeung ACM, Lui GCY, Ling L, Hui DSC, Huang D, Wong CK. Characterization of METRNβ as a novel biomarker of Coronavirus disease 2019 severity and prognosis. Front Immunol. 2023 Jan 31;14:1111920. DOI: 10.3389/fimmu.2023.1111920. eCollection 2023
  10. Cheung MK, Tong SLY, Wong MCS, Chan JYK, Ip Margaret, Hui M, Lai CKC, Ng RWY, Ho WCS, Yeung ACM, Chan PKS, Chen Z. Extent of Oral-Gut Transmission of Bacterial and Fungal Microbiota in Healthy Chinese Adults. Microbiol SpectR 2023 Jan 10;e0281422. DOI: 10.1128/spectrum.02814-22
  11. Ng RWY, Boon SS, Chen Z, Ho WCS, Fung KSC, Wong BKC, Yeung ACM, Wong MCS, Chan PKS. A cohort study on long-lasting cross-clade memory immunity following SARS-CoV-1 infection in 2003. JAMA Netw Open 2022 Dec 1;5(12):e2247723. DOI: 10.1001/jamanetworkopen.2022.47723
  12. Lai CKC, Cheung MK, Lui G, Ling L, Chan JYK, Ng RWY, Chan HC, Yeung ACM, Ho WCS, Boon SS, Chan PKS, Chen Z. Limited Impact of SARS-CoV-2 on the Human Naso-Oropharyngeal Microbiota in Hospitalized Patients. Microbiol SpectR. 2022 Dec 21;10(6):e0219622. DOI: 10.1128/spectrum.02196-22
  13. Lai CKC, Lui G, Wei Y, Chong KC, Chen Z, Ling L, Ng RWY, Boon SS, Ho WCS, Yeung ACM, Hui DSC, Chan PKS. Remdesivir reduced upper respiratory tract SARS-CoV-2 viral RNA concentration in COVID-19 patients who developed pneumonitis. J Infect. 2022 Aug 31;S0163-4453(22)00513-8. DOI: 10.1016/j.jinf.2022.08.031
  14. Chen Z, Ng RWY, Lui G, Ling L, Chow C, Yeung ACM, Boon SS, Wang M, Chan K, Chan RWY, Hui DSC, Chan PKS. Profiling of SARS-CoV-2 subgenomic RNAs in clinical specimens. Microbiol SpectR. 2022 Apr 27;10(2):e0018222. DOI: 10.1128/spectrum.00182-22
  15. Chan RWY, Chan KCC, Lui G, Tsun JGS, Chan KYY, Yip JSK, Liu S, Yu MWL, Ng RWY, Chong KKL, Wang MH, Chan PKS, Li AM, Lam HS. Mucosal Antibody Response to SARS-CoV-2 in Paediatric and Adult Patients: A Longitudinal Study. Pathogens. 2022 Mar 24;11(4):397. DOI: 10.3390/pathogens11040397
  16. Ng RWY, Wong CK, Lui G, Tso EYK, Chen Z, Tsang OTY, Boon SS, Lai CKC, Fung KSC, Yeung ACM, Ho WCS, Hui DSC, Chan PKS, Chan JMC. Case series of HIV SARS-CoV-2 co-infection in Chinese adults. J Clin Virol Plus. 2022 Feb;2(1):100062. DOI: 10.1016/j.jcvp.2022.100062
  17. Ling L, Chen Z, Lui G, Wong CK, Wong WT, Ng RWY, Tso EYK, Fung KSC, Chan V. Yeung ACM, Hui DSC, Chan PKS. Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19. Front Immunol. 2021 Dec 6;12:763292. DOI: 10.3389/fimmu.2021.763292
  18. Zhu C, Li C, Lai CKC, Ng RWY, Chau S, Wong KT, Lo NWS, Barua N, Yang Y, Liyanapathirana V, Hui M, Lai RWM, Fung KSC, Tsang DNC, Ip Margaret. Longitudinal Genomic Characterization of Carbapenemase-producing Enterobacteriaceae (CPE) Reveals Changing Pattern of CPEs Isolated in Hong Kong Hospitals. Int J Antimicrob Agents. 2021 Nov;58(5):106430. DOI: 10.1016/j.ijantimicag.2021.106430
  19. Yau YK, Mak JWY, Lui RNS, Ng RWY, Cheung KCY, Li AYL, Ching JYL, Chin ML, Lau LHS, Chan FKL, Chan PKS, Ng SC. High prevalence of extended-spectrum beta-lactamase organisms and the COVID-19 pandemic impact on donor recruitment for fecal microbiota transplantation in Hong Kong. United European Gastroenterol J. 2021 Nov;9(9):1027-1038 DOI: 10.1002/ueg2.12160
  20. Boon SS, Wong MCS, Ng RWY, Leung DTM, Chen Z, Lai CKC, Ho WCS, Huang J, Wong BKC, Fung KSC, Chan PKS. Seroprevalence of Unidentified SARS-CoV-2 Infection in Hong Kong During 3 Pandemic Waves. JAMA Netw Open. 2021 Nov 1;4(11):e2132923. DOI: 10.1001/jamanetworkopen.2021.32923
  21. Lai CKC, Lui G, Chen Z, Cheung YY, Cheng KC, Leung ASY, Ng RWY, Cheung JLK, Yeung ACM, Ho WCS, Chan KC, Hui DSC, Tsang DNC, Chan PKS. Comparison of Self-collected Mouth Gargle with Deep-throat Saliva Samples for the diagnosis of COVID-19: Mouth gargle for diagnosis of COVID-19. J Infect. 2021 Oct;83(4):496-522. DOI: 10.1016/j.jinf.2021.07.012
  22. Boon SS, Xia C, Wang MH, Yip KL, Luk HY, Li S, Ng RWY, Lai CKC, Chan PKS, Chen Z. Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach. mBio. 2021 Oct 26;12(5):e0268721. DOI: 10.1128/mBio.02687-21
  23. Subramanian R, Liyanapathirana V, Barua N, Sun R, Wang MH, Ng RWY, Nelson EAS, Hui DSC, Ip Margaret. Persistence of Pneumococcal Serotype 3 in Adult Pneumococcal Disease in Hong Kong. Vaccines (Basel) 2021 Jul 7;9(7):756. DOI: 10.3390/vaccines9070756
  24. Zuo T, Liu Q, Zhang F, Yeoh YK, Wan Y, Zhan H, Lui G, Li AYL, Cheung CP, Chen N, Lv W, Ng RWY, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC. Chan FKL, Chan PKS. Ng SC. Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity. Microbiome 2021 Apr 14;9(1):91. DOI: 10.1186/s40168-021-01008-x
  25. Yeoh YK , Zuo T, Lui G, Zhang F, Liu Q, Li AYL, Chung ACK, Cheung CP, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chow KM , Ng SSS, Li TCM, Ng RWY, Yip TCF, Wong GLH , KL Chan FKL , Wong CK, Chan PKS, Ng SC. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut 2021 Apr;70(4):698-706. DOI: 10.1136/gutjnl-2020-323020
  26. Lai CKC, Ng RWY, Leung SSY, Hui M, Ip M. Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches – An overview. Adv Drug Deliv Rev. 2021 Feb;181:114078. DOI: 10.1016/j.addr.2021.114078
  27. Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong KC, Ng RWY, Lai CKC, Boon SS, Lau JTF, Chen Z, Chan PKS. Acceptance of the COVID-19 vaccine based on the health belief model: A population-based survey in Hong Kong. Vaccine 2021 Feb 12;39(7):1148-1156. DOI: 10.1016/j.vaccine.2020.12.083
  28. Chen Z, Chong KC, Wong MCS, Boon SS, Huang J, Wang MH, Ng RWY, Lai CKC, Chan PKS. A global analysis of replacement of genetic variants of SARS-CoV-2 in association with containment capacity and changes in disease severity. Clin Microbiol Infect. 2021 Jan 30;27(5):750-757. DOI: 10.1016/j.cmi.2021.01.018.
  29. Lai CKC, Chen Z, Lui G, Ling L, Li T, Wong MCS, Ng RWY, Tso EYK, Ho T, Fung KSC, Ng ST, Wong BKC, Boon SS, Hui DSC, Chan PKS. Prospective study comparing deep-throat saliva with other respiratory tract specimens in the diagnosis of novel coronavirus disease (COVID-19). J Infect Dis. 2020 Oct 13;222(10):1612-1619. DOI: 10.1093/infdis/jiaa487.
  30. Wong MCS*, Ng RWY*, Chong KC, Lai CKC, Huang J, Chen Z, Boon SS, Chan PKS. Stringent containment measures without complete city lockdown to achieve low incidence and mortality across two waves of COVID-19 in an international city, Hong Kong. BMJ Glob Health 2020 Oct;5(10):e003573. DOI: 10.1136/bmjgh-2020-003573. [*co-first authors]
  31. Lui G, Lai CKC, Chen Z, Tong SLY, Ho WCS, Yeung ACM, Boon SS, Ng RWY, Chan PKS. SARS-CoV-2 RNA detection on disposable wooden chopsticks, Hong Kong. Emerg Infect Dis. 2020 Sep; 26(9): 2274–2276. DOI: 10.3201/eid2609.202135
  32. Wong MCS, Huang J, Lai CKC, Ng RWY, Chan FKL, Chan PKS. Detection of SARS-CoV-2 RNA in fecal specimens of patients with confirmed COVID-19: a meta-analysis. J. Infect 2020 Aug; 81(2): e31–e38. DOI: 10.1016/j.jinf.2020.06.012
  33. Lai CKC, Ng RWY, Wong MCS, Chong KC, Yeoh YK, Chen Z, Chan PKS. Epidemiological characteristics of the first 100 cases of Coronavirus Disease 2019 (COVID-19) in Hong Kong SAR China, a city with a stringent containment policy. Int J Epidemiol. 2020 Aug 1;49(4):1096-1105. DOI: 10.1093/ije/dyaa106.
  34. Ng RWY, Chen Z, Yang L, Wong OWH, Leung ASY, Tsui KW, Chan PKS, Ip Margaret. The role of gut microbiome in attention deficit hyperactivity disorder (ADHD) and its response to methylphenidate: A Southern Chinese study: a preliminary analysis. 12th Singapore Paediatric and Perinatal Annual Congress 2024.
  35. Rahman MN, Hasan MR, Akther F, Barua N, Li C, Esrafil M, Ng RWY, Ip Margaret. Efficacy of currently available antibiotics and alternatives in MRSA infections: A systematic review and meta-analysis. 19th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) 2024. Poster number 119
  36. Yang L, Zhang JZ, Ip Margaret, Ling L, Ng RWY. Machine learning-based prediction for long-term mortality following methicillin-resistance Staphylococcus aureus bacteraemia using a population-level electronic health record dataset. 19th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) 2024. Poster number 24.
  37. Ng RWY, Fung Erik, Lui LT, Chan PKS. Metabolomic profiling of COVID-19 patients in Hong Kong: a preliminary analysis. European Congress of Clinical Microbiology and Infectious Diseases 2023. Poster number 03556
  38. Ng RWY, Sapugahawatte DN, Dharmaratne P, Ip Margaret. Association between maternal antibiotic exposure and collateral effects related to microbiome changes in young children: A systematic review. Microbiome Interactions in Health and Disease 2022. Poster number 48
  39. Ng RWY, Lui G, Wong CK. Ling L, Chen Z, Wong WT, Tso EYK, Fung KSC, Chan V. Yeung ACM, Hui DSC, Chan PKS. Cytokine profile in COVID-19 patients. Health Research Symposium 2021; poster number 67
  40. Ng RWY. Bloodstream Infections by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in Paediatric Oncology Patients: Epidemiology and Clinical Outcome. 12th Western Pacific Congress on Chemotherapy and Infectious Diseases 2010; poster board number 28

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